Doubt.

If I vibecode a video game and manage to sell it on Steam, the information definitely mattered even though I didn't understand any of it.

There are drugs that nobody truly understands how they work and they are being used by professionals in actual treatments literally right now. We know purely statistical facts like "if drug X is used for condition Y it will help Z% of patients" and can only speculate as to their mechanism of action. They are used anyway and still benefit a lot of people.