I think it really depends on what the universe looks like as you drill down into it. It seems like the further down into smaller systems you get, the more analytically complex it gets. And then there will always be more value in enhancing the generalisations you have.

I would argue that novel and/or valuable results are not necessarily interesting!

I (a human) am interested in things that are applicable to my realm of understanding, but I see a very plausible future where novel and/or valuable results leave that realm.

I'd further argue that's already the case for most math for most humans. What's interesting to Terrance Tao is rarely of immediate interesting to me.