I worked in immuno-oncology: cancer vaccines work in melanoma where many things work because of the neoantigen abundance, they've generally been very mixed in efficacy. And even BionTech's BNT111 failed in melanoma! We have hope for these approaches but the reality of this stuff is way more nuanced than you think it is.

Alphafold can't reliably predict thermal energy landscapes or make functional predictions - and how could it? It wasn't trained on anything that could capture structure - function relationships.

Again, most people just have no idea how hard - fundamentally hard - molecular physics is to predict, and how necessary experiments are for any development of biological systems.