this is literally not possible. while I'm excited for these kinds of things, alphafold is already imperfect, and this basically side-steps actual structural predictions. it sounds good, but frankly biology is not there yet. in practice not even alpha fold can tell me if my gfp fusion will work...

Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...

the catch with a genome-wide map is the benchmark labels came from conservation, so you can't tell prediction from re-reading the prior.

Some more discussion: https://news.ycombinator.com/item?id=49611251