Many of the health benefits, including cardiovascular and kidney health, have been shown to go beyond or be unrelated to changes in body weight.

Lower visceral fat as a percentage of body weight may bring benefits that are greater than proportional to total body mass lost.

	▲	tptacek 39 minutes ago \| parent [-]
		Nobody's denying this, but the interesting story about GLP-1s is that after you control for fat loss (for instance, by taking cohorts of patients that aren't losing weight) you still get evidence of these off-target effects.