Ive had MTE enabled on GrapheneOS for the past 3 years for pretty much all apps I use without any issues.

Theres a couple of apps that use C++ libraries for which I disable MTE.

Most android apps using Java or Kotalin which hugely helps with avoiding buggy apps crashing with MTE enabled.

Android can and does regularly force developers to make changes to their apps to improve privacy and security on the platform. Like theyve done with other changes they could gradually force developers to fix bugs in their apps. Maybe offer a MTE opt out for apps that use memory unsafe languages.

Think its likely Apple and Google will increasingly push forward the use of MTE in Android and iOS