In the Chingichngish religion, a Datura potion was administered either once or 3 times in a person's life (puberty and, in some cultures, also marriage and before death). Not that it was a particularly widely practiced religion.

The tribes are ofc intimately familiar with the dangers of Datura. Experts that had studied the plant their whole lives were in charge of this ritual. They knew what season, what time of day, and how to harvest Datura (indeed modern science show Datura alkaloids vary drastically by time of day, weather, and environmental conditions). They also paid attention to the age and condition of the plant and the type of soil. Plants growing in indirect sunlight are less potent and preferred for initiation rituals. People undergoing the ritual had to go through a rigorous physical and dietary regime in the days preceding.

They had a clear distinction between a Datura "trance" vs just straight up delirium and the experts would closely watch the person receiving the potion to know how they are doing. The initiate is never left alone and is closely supervised during the full experience (which is multiple days)

Anyways my point with all this is that, this is NOT the same experience you get from reading some Erowid posts. Even if you are taking all the precautions. A traditional "trance" that's closely monitored by an expert is a different experience entirely.

Actually it’s entering a new era with GLP1s and peptides. Nothing will replace “our” era which ushered in bitcoin, dark net markets and hell true online community which met its end with the analogue act…

But it’s a new rebirth. Peptides are here and are unscheduled and do not fall under the analog act. Everything that was experienced in that early 10s era is happening all over again now :)

Research chemicals. Typically analogues, and stuff like that.