Acetaminophen overdose does actually have a surprisingly high rate of occurrence. A lot of people don’t realize how narrow the therapeutic band is.

Doubling your meds on a bad pain day can put you way beyond the safe limits. People think it’s safe because basically every other OTC has a huge therapeutic band, and double dosing is not recommended but not really dangerous.

CDC estimates it at 56,000 ER visits a year, 26,000 hospitalizations, 458 deaths, about a hundred unintentional deaths per year. As a point of reference, it’s about 3 accidental overdose deaths per child that dies from being locked in a hot car.