SSRIs and SNRIs just didn't work very well for me. If they had an positive effect at all, it wasn't enough to rise above the proverbial noise.

Coming off of them wasn't too bad though. I got the brain zaps, but those were easy to cope with.

More than anything the whole experience was a waste of money, and what finally fixed my problems was retirement and a greater attention to my health.

▲

litigator 12 hours ago | parent | next [-]

Have you looked into mirtazapine (tetra cyclic), vortioxetine (serotonin modulator) or atomoxetine (SNDRI). Atomoxetine has been a god send for me.

	▲	piperswe 37 minutes ago \| parent \| next [-]
		Atomoxetine can cause some wild mood-related side effects, just as an FYI for anyone considering it. For me, it made me perpetually pissed off, and made me feel like I had a cold. I’m jealous of people it works well for though - seems like a great drug when it works!
	▲	burnt-resistor 3 hours ago \| parent \| prev [-]
		I've tried 20-some-odd antidepressants titrating off and on and usually back off again. Mirtazapene (ATeCA) is the only one that could manage my depression. Unfortunately, it leads to severe weight gain that my health plan's formulary refuses to cover GLP-1 for because obesity is considered "a choice". It's the only one where the depression mostly goes away and the side-effects aren't life-threatening/-debilitating for me. If I forget a single dose at night or anytime I go to sleep without taking it first, I end up with almost exactly the feeling of an alcohol hangover. It's also a pretty powerful antihistamine. I also usually can't get to sleep if I don't take it. :/ Vortioxetine gave me horrific myoclonus and vestibular symptoms. Atomoxetine is mostly for ADHD and gave me tachycardia, profuse sweating, uncomfortable nervousness, and anxiety. It didn't do shit for my ADHD or depression. YMMV.

▲

api 11 hours ago | parent | prev [-]

They work so well for some they are miracle drugs, and for others they do nothing or have negative effects. This is typical. We still don’t fully understand why or even why they work at all.