There's A LOT low hanging fruit still out there for sure. And with antigenic systems being able to do the boring repetitive work of looking for that low hanging fruit I think we will see interesting things indeed. Also I think heuristics is where its at for such things. Once you describe some good heutistical structures for the research models to always follow related to "creativity" and such things, thats where we will see biggest difference. The agentic systems know the scientific method well and can follow it they just need the ability to be "creative" so their sampling becomes less rigid.