I feel like it's the kind of thing you might wind up caring about if you're micro-optimizing your python, but in my experience that's a losing game and you're better served rewriting it in another language than bothering with trying to speed up the execution of the raw python code (it's not that you can't optimize python code, but only in broader strokes. If you are looking at the bytecode you're in too deep and every time I've seen it tried the code has been ported shortly afterwards).