I’m willing to bet we can see longevity improvements from better blood sugar control. Not 100% certain but extremely likely, this would include potential heart attack and dementia reduction…

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novok 2 hours ago | parent | next [-]

IMO blood sugar is too simple and focused on because of ease of measurement. Someone can have rollercoaster blood sugar and be far more metabolically healthier than someone with low and steady blood sugar. Continious insulin and cortisol monitors are far more interesting IMO

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malfist 6 hours ago | parent | prev [-]

This has been tested actually. A clinical trial looking at tight blood sugar regulation was aborted after it resulted in multiple cardiac events.

	▲	RHSeeger 5 hours ago \| parent \| next [-]
		That's not a fair representation of what happened. That study was going for _aggressive_ control - beyond what any normal person would do. They were combining multiple drugs to force blood sugar down rapidly, including right after meals (when it _should_ be going up). Paying more attention to your blood sugar and acting reasonably to keep it in check isn't giving anyone heart attacks. From the AI > The concern was not that lower glucose is inherently bad. Rather, pushing blood sugar down rapidly and very tightly—especially with insulin and multiple glucose-lowering drugs—caused more episodes of hypoglycemia, weight gain, and treatment complexity. Severe low blood sugar can trigger abnormal heart rhythms and other cardiovascular stress. The intensive-treatment arm was stopped early after about 3.5 years because it had a higher death rate, although the exact mechanism was not definitively established.
	▲	adinisom 5 hours ago \| parent \| prev \| next [-]
		Interesting! Found this overview: https://emcrit.org/pulmcrit/tight-glycemic-control/
	▲	4 hours ago \| parent \| prev \| next [-]
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	▲	andy_ppp 2 hours ago \| parent \| prev [-]
		Nonsense, you can fast or live in ketosis for years without any adverse consequences.