Early-life stress leaves a 'scar' inside brain cells in mice

anigbrowl 5 hours ago | parent | next [-]

Not to play down anyone's stressful life experiences, but the sort of stress they're talking about in this article is more typically correlated with stressors like violence, hunger, or institutionalization in the first decade of life.

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genxy 3 hours ago | parent | next [-]

So millions of kids in Gaza. :(

	▲	philipallstar 23 minutes ago \| parent [-]
		The population of Gaza in total is about 2 million. You're right that about half that population is 20 or younger, and so they've had up to 20 years of genuine indoctrination, Hitler Youth-style, which is some horrible level of trauma, but that's their parents' terrible shame for voting in Hamas in 2005, who spent billions in aid on trying to figure out how to destroy Israel.

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thibaut_barrere 2 hours ago | parent | prev | next [-]

I do not read this in the article, I was more understanding that half the kids of the world could be concerned to a level or another, can you quote?

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soulofmischief 3 hours ago | parent | prev [-]

Great, I had all three of those in large helpings. :)

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redrix a day ago | parent | prev | next [-]

I remember having it drilled into me in High School that unless you did well on your finals:

1. You wouldn’t get the score you needed to get into a good University and/or accepted into the course you wanted. 2. If you didn’t get into that course, you wouldn’t be able to do <x> for a career. 3. If you DID get into the course you wanted, it needed to be at a top University (which of course required an even higher entry score) or else you’d find it hard to get a job afterwards.

Imagine all of that stress: Telling 16-18 year olds that unless you ace your tests, you won’t be able to do what you want to in life.

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syllogism a day ago | parent | next [-]

The optimal amount of stress about that stuff is not zero, and most teenagers are going to be desperately biased towards "none of this matters, just peermax".

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InterviewFrog 4 hours ago | parent | prev | next [-]

Alexander the Great won his first battle at the age of 18.

Treating 16 to 18 year old like 5 year olds is not the right way to go about it.

	▲	asphodele 2 hours ago \| parent [-]
		Sitting Bull killed his first buffalo with bow and arrow from horseback at the age of 10.

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golly_ned a day ago | parent | prev | next [-]

I don't think that's what they mean by 'early-life'.

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coldtea a day ago | parent | prev | next [-]

The healthy reaction for 16-18 years old is to not give a damn about that, rebel, and discover the other (or the same) sex and partying.

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NewJazz a day ago | parent | prev | next [-]

I remember having it drilled into me in high school that I was procrastinating school work while at my mom's to avoid spending time with my dad and I was faking my sobbing for sympathy and I was a horrible person who was lucky to have a dad as good as I had and how I keep doing the same things wrong and I am a smartass prick who doesn't care about anyone but myself.

12-14 was rough.

School work stress was quite tame by comparison. At least your teachers don't scream at you for hours until you forget why.

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squigz 13 hours ago | parent [-]

This is what I think of when I think of "early life stress" in kids - not worrying about school.

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mrguyorama 12 hours ago | parent [-]

It's called "Adverse Childhood Experiences", or ACEs, and the field of psychology has found them to be extremely good predictors of future negative outcomes for a long time now.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8882933/

Things like abuse, neglect, natural disasters, basically anything that can cause trauma or significant stress.

Be a toddler and your mom's new boyfriend abuses both of you? Congrats, you brain has developed in a way that will not be conducive at all to your future, because instead of developing a functional reward system, you've developed a specific hyperawareness to manage the difficulty of living around one kind of abuser. This incredibly specific adaptation will of course, not prevent you from being an easy target for an entirely different type of abuser in high school.

(It's actually not that simple of course. Multiple ACEs are predictive of future troubles, not just one, so it's more like "A child who lives in an environment of constant stress, fear, and pain is likely to have a brain that didn't develop well" with a direction of effect unstated)

This is one reason why things like abuse and poverty are so damn cyclical. Your parents grew up in poverty and with abusive parents, so they have an elevated chance to abuse their children, and on and on and on.

This is also one reason why something like "Free food at school for anyone who wants it" is so damn effective, because it eliminates an entire class of ACEs from all those kids, and in the US, it also eliminates the horrific humiliation machine we've built around paying for school lunch, which might not be the best way to raise kids anyway.

	▲	mjevans 3 hours ago \| parent [-]
		It takes a village is so true. Children are something society as a whole should invest in, and fails to do so at risk to it's own future. By society, I mean every one of us that plans to grow old instead of an early death. Wouldn't it be nice to have two or three or ideally more generations of well adjusted people that grew up not fearful of hunger, nor lack of basic shelter, medical care? Also, providing quality child care for any time the parent(s) are working frees up quality workers to do that... though a better work life balance would also help society.

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porridgeraisin an hour ago | parent | prev | next [-]

Is it wrong?

	▲	wiseowise an hour ago \| parent [-]
		There are many things in life that are “not wrong”, doesn’t mean you have to scar kids for life with this shit.

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euroderf 20 hours ago | parent | prev | next [-]

Not to mention having all this on your permanent record.

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leoh a day ago | parent | prev [-]

I remember having this in middle school, it was a nightmare and majorly fucked me up

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ls612 a day ago | parent | prev | next [-]

In mice.

	▲	dang 14 hours ago \| parent \| next [-]
		Inmiced above.
	▲	leoh a day ago \| parent \| prev [-]
		"In mice" is the right caveat for outcomes and the wrong one for mechanisms. Nobody’s selling you a drug here--they’re describing a chromatin change, and that’s the part rodents are actually good for. The alternative study design is randomizing infants to early-life stress and biopsying their hippocampi at 30. Committee’s still reviewing it.

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sph a day ago | parent | prev | next [-]

These pop-sci articles annoy me greatly. All I can think reading the title is “well, duh?” - they’re a complete tautology.

Let me explain: if an event or behaviour affects a person, it means that there must be a physical record of it. These types of articles confirming that such a record has been found might be great news for researchers, but for everyone else, the existence of this physical record was already known a priori. We are biological machines after all, all behaviours are encoded physically.

If there was no such scar in brain cells, there would have been no early-life stress.

This applies to other research such as “learning changes structure of the brain” or “drug addiction turns off specific neural pathways” or “brains of children with autism differ from neurotypical brains” or “athletes have more developed muscles”

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Byte-Naut 3 minutes ago | parent | next [-]

We do all know experience has its substrate, but one thing matters more—are they encoded as stubborn neural connections, mitochondrial damage, epigenetics, or something else to transform it into depression, long-term inflammation, or stress susceptibility, etc.? The current evidence emphasizes the latter. Only if we know what the 'it' is, do we have chance to change, rather than just knowing it exists.

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T-A an hour ago | parent | prev | next [-]

> if an event or behaviour affects a person, it means that there must be a physical record of it

Yes, and it (or at least one of them) has now been found. Maybe you don't care about knowledge for its own sake, but as the "irritating" press release goes on to point out,

“There are currently no treatments for what early-life stress does to the brain, partially because we have not had a clear picture of what molecular mechanisms to target,” Peña said. “This work is exciting because it reveals a clear mechanism, and also helps explain why the impact of stress is both latent and broad.

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mattmcknight 7 hours ago | parent | prev | next [-]

Scar is also a very loaded word to use here for something that is not a scar.

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hamper653 20 hours ago | parent | prev [-]

> Let me explain: if an event or behaviour affects a person, it means that there must be a physical record of it.

That record needn’t be inside individual brain cells.

	▲	oharapj 7 hours ago \| parent [-]
		It also doesn’t need to be a scar.. much easier to explain things as obvious post hoc than to predict them I fear

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jdw64 a day ago | parent | prev | next [-]

Then my brain must be full of scars.

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nemosaltat a day ago | parent | prev [-]

When our Little, Stuart falls down we don’t even know what he remembers. [in mice]