Possible path for organic zero calorie sugars!

L-Glucose already exists, but the problem is that the amount in, e.g. one soda would make your intestines decide to entirely empty themselves. It's been trialed as a colon-cleansing agent for colonoscopy in much smaller doses than say a can of Coke would need, so it's not very useful in a consumer product.

Posted elsewhere in the comments:

https://laprade.blog/your-dietbet-destroyed-the-world