They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

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gruturo 4 hours ago | parent | next [-]

They do slow down the metabolism, yes.

They seem to also act on some reward mechanism - making some stuff (not just food. Alcohol, gambling, porn, smoking, other drugs have anecdotally been reported to feel less attractive / addictive) have a reduced pull on one's will. They also measurably delay gastric emptying - to the point that some medicines, meant to be taken on an empty stomach, are not safe to take within up to 3 hours from the last meal, compared to one hour or so for other people.

	▲	eapressoandcats an hour ago \| parent [-]
		It’s not clear to me that they slow down metabolism consistently, although that does seem to be the effect in some people. I rather think the opposite is true, that by increasing signals that the body is satiated in many cases it is avoiding a metabolism slowdown caused by hunger.

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SubmarineClub 4 hours ago | parent | prev [-]

> metabolic changes that make weight loss harder

Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

	▲	eapressoandcats 2 hours ago \| parent \| next [-]
		That’s very nice for you, but it is a phenomenon that is well documented by research: https://pmc.ncbi.nlm.nih.gov/articles/PMC4989512/
	▲	preg_match an hour ago \| parent \| prev [-]
		Your body naturally tries to maintain homeostasis. When you cut your food supply below what your average is, and probably has been for years, your body will fight you in every way it can. For example, I eat too much and started eating less. I now eat normal portions instead of portions fit for 2 people. I have more than enough food and energy, and yet, I am hungry. The hunger is fake, I certainly don’t need more calories. But my body thinks it does based off of its knowledge.