Doubt you can eat just pure fructose for 30 years and ”move” and avoid diabetes.

At the risk of being argumentative I had a horrible diet for the past ~10 years and carried 50 extra pounds. However I also exercised a lot as a hobby and to my shock my glucose and other bloods always came out in the normal range.

This year I started Mounjaro and dropped the 50 pounds. Curious to see what my next checkup shows.

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AlexErrant 7 hours ago | parent [-]

People kick around the idea of the "personal fat threshold". E.g. caucasians seem to be better at carrying fat than, say, Southeast Asians. White people seem to be able to better store fat without metabolic side effects; SEA seems to get T2D at a much lower bodyfat percentage.

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zemvpferreira 5 hours ago | parent [-]

Possibly maybe, but plenty of caucasian friends at my old bodyweight/fat percentage had/have horrible markers. I lean more towards the protective effect of exercise.

	▲	AlexErrant 4 hours ago \| parent [-]
		Agree 100%. To quote myself: --- Which do you think is worse: smoking, or not exercising? https://jamanetwork.com/journals/jamanetworkopen/fullarticle... Look at Figure 2C in particular. The hazard ratio of smoking is 1.41. The hazard ratio between "Low" (<25th percentile) and "Below Average" (25th-49th percentile) cardiovascular health is 1.95. In other words, it is better to be a smoker than in the lower 25% of non-exercisers. By far. It's not even close. https://news.ycombinator.com/item?id=40080849 Let me emphasize: that exercise hazard ratio is between LOW and BELOW-AVERAGE.