I use Firefox with (non-lite) uBlock Origin, and occasionally fire up Chrome (with uBO Lite) for testing. The main issue that I run into is that uBO lite filters can't vary per-domain, so in order to rule out an ad-blocking-false-positive on something I'm developing, I have to turn it off for _all_ sites, not just localhost. (Actual false positives are rare, but needing to check is not so rare.)

That's not true, the on/off toggle is per-site in uBlock Origin Lite.