If you are just trying to get something quick and simple that works for rendering react components then this repo is solid:

https://github.com/marcomattes/epaper-components/tree/main

The Bigme is a pretty high quality eink display, but some core properties of eink are present here so I’ll offer some generic guidance:

The contrast on any epaper display is lower than on a modern lcd/oled display. So you want to avoid or modify ui systems that try to diminish contrast for stylistic reasons. Or more explicitly: maximize the contrast wherever legibility matters. It is pretty common in pretty much every modern design system for web/mobile to diminish contrast so you may just need to go in and tweak things yourself.

Second: you cannot rely on color as an accent. A lot of UI does this (submit buttons). Defining a consistent accent pattern is necessary to replace patterns that rely on color. This can be outlines/borders or inversions.

Stylistically I think that sharper content looks better on eink than smoother content, but on a 300 dpi display with 16 grays this is less of a hard point.

Cheers, will check that repo out.

>you cannot rely on color as an accent

Yeah definitely found this using some 'normal' webapps, default dark mode makes it worse too.