No. They're metabolically equivalent. "High fructose" corn syrup is "high" relative to normal corn syrup, not relative to sugar, some of the HFCS formulae in packaged food has less fructose than table sugar, and, most importantly, your body is a well-oiled machine at breaking down sucrose, which is cleaved enzymatically immediately upon it entering your gut; there's no material slowdown in digestion from eating sucrose.

(The key thing to remember is that sugar is bad for you; it's not that HFCS is good, but rather that cane sugar is just as harmful.)

Two fun additional notes:

* There's a video somewhere showing how cane sugar breaks down into fructose and glucose in bottled sodas anyways, and

* Perhaps unsurprisingly, taste testers can't reliably distinguish between HFCS and cane sugar formula Coke.

Yeah, a big part of the flavor difference between Mexican Coke and American Coke really comes down to the extra sodium in the Mexican Coke variety.

You can get the US formula coke with cane sugar during Passover in markets with a high Jewish population. Taste it, it'll be practically the same as HFCS US Coke and not like Mexican Coke. Because, it has the same amount of salt as the US variety.