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Midlife Vascular Risk Burden and Dementia-Free Survival Years(neurology.org)
67 points by bookofjoe 5 hours ago | 52 comments
asdfman123 4 hours ago | parent | next [-]

Yes. The time to fix your health is now. Any unhealthy habits put time on the biological clock, and they'll just get harder to undo later. This is true if you're 20, 40, or 60. Plaque even starts building up on the arteries of healthy teenagers. It all adds up.

But don't read this and panic or beat yourself up, that's a waste of energy. That's choosing the punishment instead of the fix.

Instead, quietly start doing one small healthy habit. If you stop, don't revert to self-punishment again. Just quietly get back to it. Stubbornly persist until you've won.

asmodeuslucifer 2 hours ago | parent | next [-]

I just watched this video by a doctor, and his point was every one of his ER patients had a problem that was years in the making (except for 1, a little girl who swallowed a battery)

I Saw 120 Patients This Week. Here's Why They Were Actually Sick. https://www.youtube.com/watch?v=UiVKh97rJsg

scottious 43 minutes ago | parent | next [-]

It is a bit crazy that everybody seems to agree that diet and exercise are important, and yet it seems like society is hell bent on making those things very hard to do well.

I went to the mall recently (big mistake) and I had to get lunch at the food court. I don't think there was a single gram of fiber across the 10 or so restaurants. So much of America is drive-thru garbage. Yup -- you don't even have to stand up to get your Big Mac. You can endanger other people by eating it while you drive.

We tell people to get exercise and then force them to have 9-5 desk jobs that have a 45 minute car-commute each way. And what's so much worse is that people are paying a ton of money for that car that's slowly killing them. It's not entirely their fault though -- that's just the way our society is set up. Walkability is a luxury only the rich can afford.

Then, 20 years later you show up to the doctor and the standard course of action is to prescribe a bunch of medications. The doctor says "you should exercise more and eat better" and many people just don't.

So much is broken.

WarmWash 33 minutes ago | parent [-]

Exercise is taxing, and healthy food isn't as tasty or easy as junk food.

Humans are natural experts in min-maxing calories spent vs calories consumed. Then we solved food ~100 years ago and its been a kid in a candy shop ever since.

citrin_ru 3 minutes ago | parent | next [-]

> healthy food isn't as tasty

Mediterranean cuisine tasty and healthy. But it’s not as cheap as ultra-processed food.

Insanity 21 minutes ago | parent | prev [-]

Gotta find exercise that is fun though. Don’t just try one thing and give up, it takes time to find what you enjoy.

I’ve been swimming for 15 years, but only got into bouldering 1.5 years ago. I tried running and cycling but it always felt like a chore so I could not stick with it.

The food problem is much harder to solve for IMO, even shops are designed to get you to impulse-buy junk. Although one minor tip is to do groceries when you’re full, not when you’re hungry.

vhcr 27 minutes ago | parent | prev [-]

The kid dying is sad, but it could have probably been prevented if the batteries were coated with a bitter agent such as denatonium.

throwawalien 3 hours ago | parent | prev [-]

yep.

eat healthy food as much as possible.

walk. exercise. and SLEEP.

asdfman123 3 hours ago | parent | next [-]

IMO developing good sleep hygiene is by far the most important habit to cultivate.

It has lots of benefits, but the most important one is it replenishes your willpower. If you're trying to develop other healthy habits, it's 10x harder if you haven't slept well.

mattv8 2 hours ago | parent [-]

It's also the easiest to implement, imo. But there is a tradeoff: fewer waking hours during your best years cognitively for more years when you're older...

Touche an hour ago | parent | next [-]

Poor sleep is a widespread problem and very few of those people are cognitively doing it intentionally as some sort of "tradeoff". The number of people "grinding on a startup" is tiny compared to the population of people who suffer from this problem. Instead it's caused by things like general anxiety, too much screen time before bed, or not having consistent sleep schedules. And other health related reasons that compound the problem.

sersi 39 minutes ago | parent [-]

You can add having a child to the list. Nothing has caused more disruption to my sleep as my son has done

Centigonal 2 hours ago | parent | prev [-]

Waking hours is both a quantity game and a quality game. I don't remember too much from the parts of my life where I was very sleep deprived

lukan 3 hours ago | parent | prev [-]

"eat healthy food as much as possible."

I usually stop, if my body signals me I had enough.

(might seem like pedantery, but I know some people do believe it literally, that it is healthy to just fill themself up with "healthy food", but it is not).

bookofjoe 2 hours ago | parent [-]

I think the commenter meant such that as much as possible of your diet consists of healthy rather than unhealthy food — NOT as great a quantity as you can take in.

lukan 2 hours ago | parent [-]

I know, I took the literal meaning because I know some do live by that.

bookofjoe an hour ago | parent [-]

Fair enough! Just because I don't doesn't mean I shouldn't broaden my scope.

sys32768 an hour ago | parent | prev | next [-]

It's mostly luck and genetics, but good sleep matters.

My mother died from Alzheimer's at 77 but wrote down her symptoms as early as 60, a full six years before her diagnosis.

Prior to her diagnosis, she walked her dog two miles a day, had an ideal weight, ate organic, never drank or smoke, used her brain constantly, and enjoyed a happy social life.

The only problem I saw with her was she was a very light sleeper.

Her aunt also died from Alzheimer's and was super healthy when diagnosed too.

Meanwhile the 103-year-old lady at my mother's former care facility is still sharp as a tack and reads daily without needing glasses.

highfrequency an hour ago | parent [-]

Are you aware of her APOE3/APOE4 status?

sys32768 43 minutes ago | parent [-]

Nope.

I have one APOE4.

Her mother didn't get Alzheimer's until her mid-80s.

brandonb 4 hours ago | parent | prev | next [-]

Previous studies have shown that heart health at 50 predicts brain health at 75.

This study is interesting in that it quantifies the benefit as 12.5 extra dementia-free years. People with 0 risk factors had 30 years of dementia-free survival, vs 17.5 years for people with all 3 risk factors measured.

The risk factors in this specific study are blood pressure, diabetes (HbA1c), and smoking. You could reasonably also include cholesterol/ApoB, inflammation (hs-CRP), and perhaps Lp(a) as potential risk factors.

nickjj 36 minutes ago | parent | prev | next [-]

If anyone wants to go down a rabbit hole, go search for topics around fructose corn syrup, visceral fat and artery plaque. It can play a substantial role in vascular health. I'm not a doctor but there's a bunch of studies posted online about this and my doctor also agreed when I asked him about it.

Avoiding fructose corn syrup is a really good idea. It's in a ton of sugary drinks. It really messes with inflammation in your body and your liver materializes it in a very similar way as alcohol. Basically both are bad and can cause similar issues.

For me personally I walk a few miles a day for 15+ years and I'm in ok shape. Cutting out Arizona iced tea (has a lot of fructose corn syrup) has made a material difference in how my body operates, I used to drink 1-2 cans a day for a while. Nowadays going 18 hours without food is no problem, I don't have mid-day tired spikes and I didn't change what I eat. I can't explain it but it feels like it reset something.

When I've been on vacation in other countries outside of the US for a few weeks, I noticed the same thing (less hungry, more energy, etc.) and a commonality there is I also didn't drink large amounts of fructose corn syrup. There's a lot of variables I'm sure but I can say I feel a difference for the better after stopping and I've now repeated these feelings when doing normal things locally.

johsole 3 hours ago | parent | prev | next [-]

The importance of walking can not be overstated. Walking for 30 mins every other day will dramatically improve your life if you are sedentary. If you can't do 30 minutes, start with 15.

scottious 36 minutes ago | parent | next [-]

For those who are inclined, I recommend running instead (even if you think you aren't a runner)

My body has been completely transformed from 15 years of running. I'm 5'7" and 135 pounds at age 41. My face looks thin, I have a better body than most 20 year olds. I gave myself the best gift that I could possibly give myself.

If they could distill 15 years of running (5x per week) and put it in pill form, I truly believe it would be the most valuable thing medicine has ever created.

All it takes is 45 minutes per day for 5 days per week. And you can actually have fun while doing it! It takes a long time to get to that point but it's so worth it.

phainopepla2 25 minutes ago | parent [-]

For those who are a bit intimidated by the thought of starting running, especially if you are a bit older, you don't need to run hard or fast. Slow jogging (zone 2) results in great cardiovascular improvements. Don't be afraid to start by alternating jogging and walking.

And if you can't spare 45 minutes 5 days per week, do it 3 days a week instead. Something is better than nothing.

sublinear 3 hours ago | parent | prev | next [-]

Lifting weights also helps.

I'd argue that if someone wants to go beyond walking into running or even jogging, they ought to get their strength up so they don't have blood sugar crashes or cramps. It's never a bad idea to gain some muscle.

intrasight 3 hours ago | parent [-]

And don't drink alcohol

steve_adams_86 an hour ago | parent | next [-]

I'm not a drinker, but I think we shouldn't be so strict about it. I usually have a drink once every few months or so, and frankly I don't really care about the impact it has on my health. I suspect it's so minuscule as to not matter at all in the scheme of things.

Same with eating deep fried food. Especially if it's a food that's otherwise quite healthy. A bit of hot oil isn't going to be your undoing. Just don't make these things a habit. Enjoy a bit of indulgence, but be honest with yourself: is this once per month thing becoming a once per week thing, or a once every few days thing? Daily? Don't do that. Recognize vice. But don't be so strict that you never allow anything remotely unhealthy. Humans aren't great at abstinence.

Having said that, there's a reason I don't drink more often and it's because it really is terrible for you. I agree, haha. Just, don't pretend you'll never do bad things ever again. Unless you have far more willpower than I do — that's entirely possible.

KPGv2 24 minutes ago | parent | prev [-]

Also stay out of the sun. Better yet, just do a treadmill inside. No skin cancer that way.

jr3592 2 hours ago | parent | prev [-]

Had an uncle who swore by this. He died at 57 of ALS.

That obviously doesn't mean walking is bad, I just mean to point out that even those people who believe in it as a silver bullet, can be hit with something totally out of left field.

Life is really quite brutish and short. You can do all the right things, and die early. All the wrong things, and live a long time. Take care of yourself for sure, but also find a balance and enjoy your life.

Aurornis an hour ago | parent | next [-]

Almost nobody believes it's a silver bullet or perfect shield against disease.

It's an odds game. I don't encourage people to start going into the long tail of diminishing returns to improve their longevity at the expense of everything else, but low hanging fruit like going for a walk every day has a very high ROI in later life quality of life.

BXLE_1-1-BitIs1 2 hours ago | parent | prev | next [-]

You can do everything right and get taken out by an accident. So far I've dodged a loose trailer that came off next to me going the opposite direction, a rock dislodged by a marmot from the cliff above, two drunk drivers drifting towards me, a city bus turning towards me on an icy road, a few other left turning drivers who didn't see me in a crosswalk (I now carry a high intensity pulsing flashlight for crossing at intersections) and two near misses when a gust upset my glider.

switchbak an hour ago | parent [-]

I was almost taken out by two rogue kayaks being towed behind an oblivious truck driver.

If I get taken out, I want it to be while I'm saving kids from an angry bear, not something stupid like ^

coldtea 40 minutes ago | parent [-]

>I was almost taken out by two rogue kayaks being towed behind an oblivious truck driver.

Wow! That's some luck!

Movie night suggestion: Final Destination 1 and 2

coldtea 41 minutes ago | parent | prev | next [-]

Nobody thinks of it as a silver bullet. They know they can still get cancer, or get hit by a car, or whatever else.

striking an hour ago | parent | prev | next [-]

Fine. But walking is also just kind of nice and unobtrusive for most people. I'd understand if you were replying to someone telling you to do strength training, but I'd argue walking is just pleasant.

KPGv2 an hour ago | parent | prev | next [-]

The construction of GP and your post in sequence implies you think walking is not enjoyable.

GP: Go walking.

You: Instead, find a balance and enjoy life.

Walking is very enjoyable. Try it! Bonus, you'll come up with some of your best ideas!

adammarples an hour ago | parent | prev [-]

Nobody thinks walking is a silver bullet, ie a cure all. It's a good preventative for the most likely cause of death (heart disease).

ajx1001 3 hours ago | parent | prev | next [-]

The work of Dr. Rick Johnson is perhaps relevant. He links the effects of fructose on the mitochondria, which then affects the neurons in the brain, over time.

This hypothesis makes much more sense to me when you think to the associated diseases (diabetes, heart disease etc...)

You can get a overview of his research on this podcast (approx 75min): https://www.youtube.com/watch?v=59Oje6n2JLU

n8henrie 2 hours ago | parent [-]

In the context of TFA, what hypothesis makes much more sense to you than what alternative?

John7878781 2 hours ago | parent | prev | next [-]

I have always had a very low blood pressure, below what's considered "normal." I never feel dizzy when standing up, though. Is this still a risk factor for dementia?

organsnyder an hour ago | parent [-]

This is a question for your doctor.

Aurornis 3 hours ago | parent | prev | next [-]

> Maintaining optimal midlife vascular health was associated with up to 12.6 additional dementia-free survival years,

Stay on top of your cardiovascular health. Even moderate diet and lifestyle changes can have a significant impact on the last decade of your life. These things compound over decades.

criddell 2 hours ago | parent [-]

Being human, I think more about the number of dementia years than number of dementia-free years. Could having good dietary, sleep, and exercise habits result in living longer with dementia?

I've hard about cognitive reserve and how healthy lifestyle choices can build that. But I never read about ways to minimize the number of years you have to live with dementia. I wish I could sign an order that would grant me a dignified death once I'm deemed no longer fit to make that decision.

Aurornis an hour ago | parent [-]

You're looking at this from the wrong angle. The dementia risk and longevity have overlapping factors. Lifestyle choices correlated with shorter lifespan are also correlated with earlier dementia onset. They're not perfectly proportional, but getting earlier dementia and also living shorter is lose-lose.

Technically there's an extreme version of this where someone's lifestyle is so bad that they're unlikely to live past 60, but the last 10-20 years of that life would not be fun.

_wire_ 2 hours ago | parent | prev | next [-]

You are going to die, and it's a painful ugly business.

The right to die humanely is the single most under-regarded and under-valued aspect of life hygiene.

tejohnso 2 hours ago | parent [-]

Fortunately some jurisdictions are death wise enough to provide humane means that we can request from a health practitioner.

switchbak an hour ago | parent [-]

That cuts both ways though, and I have quite direct knowledge of how this has been misused in really gross ways. But that said, I would still bias towards more freedom than less, and hope that we can get a handle on the more extreme cases.

sublinear 3 hours ago | parent | prev [-]

> Hypertension was defined as a systolic blood pressure of 140 mm Hg or higher, a diastolic blood pressure of 90 mm Hg or higher, or the utilization of blood pressure-lowering medications.

Whoever defined this, thank you for having common sense!

This stood out to me because there are so many lunatics defining it as 121/80 or even 121/70 with the backwards idea that the systolic is more important. Worse still is when they insist that something as low as 100/65 is optimal despite complaints of dizziness. All the while hammering home that you should chug a million gallons of water and deprive yourself of sodium. It's like they're trying to make people miserable.

hombre_fatal 2 hours ago | parent | next [-]

The 120/80 benchmark isn't lunacy. Most people in the west have issues with hypertension because that's the direction it goes due to the common risk factors.

If you're at 135/85, and you're middle aged / younger, and your diet and lifestyle aren't already optimized, it's something you should probably care about, not look for the next highest rung on the ladder so that you can celebrate for being below it.

sublinear an hour ago | parent [-]

You're completely missing the point. There's a significant amount of people middle aged and younger with numbers something like 125/75. They may have that same blood pressure never change from about 20 years old until their 70s.

Elsewhere they'd be borderline normal, but "in the west" (really just the USA) they're considered stage 1 hypertension and it's anyone's guess what wild nonsense the doctor will tell them once that's in their chart.

It's a total circus. Covering your own ass and screwing the patient over by assuming the worst is not preventative medicine. Overprescribing medication would cause harm if the patient is too naive for their own good despite doing everything else right. Nobody in their right mind should listen to that kind of doctor or take the medication.

KPGv2 22 minutes ago | parent | prev [-]

The blood pressure-lowering medications was a kick in the crotch. I've had primary hypertension (i.e., doctors have no explanation for why) since I was a teenager playing fifteen hours of tennis a week with a low body fat percentage and healthy eating habits.

Nothing I've ever tried has fixed this, including scratch-cooking everything for months, no meat, no salt, for months. Distance running. Weightlifting. Lots of sleep. I literally don't even have to work the rest of my life and am in my 40s, so no stress, either. I guess I'm just screwed!