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qnleigh 2 days ago

This specific study sounds relatively benign, but generative models for DNA sequences sounds like an incredibly dangerous technology to develop. If someone were to reproduce their study while including animal viruses in the training data, what would it be capable of? And what about after a few years of progress?

Their phages have only 5400 base pairs, but the hepatitis virus has around 3000, and ebola only had ~19,000. That doesn't mean making a novel lethal virus is easy, but if anyone pulls it off, it would make Covid look like a picnic.

lefty2 a day ago | parent | next [-]

Don't worry, if it escapes from the lab we can just blame it on the bats again

beej71 a day ago | parent [-]

Edit: I take back my snark.

I never understood the "it's really important for us to blame the lab leak" angle. I certainly want to know what actually happened, but some people really, really want it to be a lab leak. Perhaps you can explain?

AngryData a day ago | parent [-]

If it is a lab leak people can blame other people for the disease. If it is naturally occuring there is nobody to blame and people have to face the idea that nature can still kill them at anytime and justifies lock downs and restrictions when dangerous diseases arise.

beej71 a day ago | parent [-]

But don't lab leaks that result in pandemics still require lockdowns and restrictions when dangerous diseases are leaked?

AngryData a day ago | parent [-]

It should, but some people don't care as long as they can put the blame of any consequences on somebody else. It lets them push the responcibilty of their own actions onto others.

spwa4 2 days ago | parent | prev [-]

We have 5 known antibiotics. There are "MRSA" bacteria (which is a property of bacterial species, not a name for a particular species (anymore)) which don't care or react to about 4 of them and the 5th one is showing slightly reduced effectiveness already.

Why? Presumably because, of course, the new government rules imposed on doctors for antibiotics are about saving money and NOT about fighting resistance. The 5th antibiotic is ... not expensive in an absolute sense, but compared to the other 4 it's pretty expensive. The guideline from scientists is that if you decide to use it you need to nearly overdose the patient on it, despite that that is not necessary to cure them. Doing that is much more expensive (not that much more expensive really, it just looks impressive in % and presumably in excel sheets), but fights resistance. We're not doing that, and so we have ... probably not even a decade ... and then we have no treatment anymore against bacterial infection.

And in a decade, we will still be surrounded by lethal bacteria. Look at your hand. It's overwhelmingly likely you can't see them but you're looking at lethal pneumococci, several species. This is a clean hand we're taking about. Even a freshly scrubbed hand of a surgeon will still have quite a few bacteria. Grab a handful of soil. You know, the kind plants grow in. Your hand now has botulinum-producing bacteria, as well as many other toxins, tuberculosis (definitely if you're anywhere near a farm), tetanus, and the list goes on and on), some of which we have no vaccine against at all, and many we don't vaccinate for because it's not practical.

So the choice is between developing DNA sequences for viruses, or having a pandemic 100x worse than COVID every 30 years or so.

There is no choice here.

qnleigh 15 hours ago | parent | next [-]

What you say would make sense if phages designed from scratch with generative AI were the only solution to antibiotic resistance. That's obviously not the case.

tim333 a day ago | parent | prev | next [-]

Googling the 5 known antibiotics comes back

>There are actually dozens of individual medicines and more than ten major classes of antibiotics used to treat bacterial infections—not just five

qsera 2 days ago | parent | prev [-]

Jesus, how are the other living things existing at all?

pixl97 a day ago | parent [-]

You should hear about the war that occurs in the ocean non stop. Quadrillions of bacteria, bacteriaphages, and viruses are in a constant battle and evolving to one up each other.

Really I don't get how multicellular life survived it.

qsera a day ago | parent [-]

Why go to the ocean, because that happens everywhere, non-stop. If your immune system stops working, then you are a dead man.

a day ago | parent [-]
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