Skin is so interesting as a surface to think about how light passes through and bounces off of.

There is at least one article published by a technical artist at Pixar who describes modeling a skull within a human scan so that subsurface lighting is more accurately rendered.

I suspect you could combine this with dr_scully’s comment and GolDDranks’ to reach the nuance involved in long tail realism details.

There's a lot of really good research papers that touch on this area from what I saw - would definitely be cool to see if that extra nuance could be added without dramatically increasing the math complexity; in its current state, the code could be used in any programming language without a library.