I worked for a company that had a fairly large OpenVMS installation and had to make the transition from Alpha to Itanium. It required a considerable amount of work and the early iterations of Itanium did not provide a clear performance improvement over the final Alpha EV7z that we had been using in some GS1280s.

Going by my faulty memory, I'd say it wasn't until Tukwila that it was a clear win over Alpha EV7z. By the time Tukwila arrived, it was pretty clear that Itanium's goose was already cooked.