Aspirin reverses diet-driven depression-like behavior

Actual title: Aspirin reverses diet-driven depression-like behavior in mice

I'll let my mouse know

u1hcw9nx 11 hours ago | parent | prev | next [-]

... in mice.

More than 90% of "in mice" studies do not transfer to humans.

I wonder how often a medicine that would have worked in humans doesn't transfer to mice, resulting in it being rejected.

	▲	tusimi 10 hours ago \| parent [-]
		all the time. lack of appropriate/translatable preclinical models is one of the largest barriers to new meds. in practice, if you can't find a mouse that has the same disease its almost impossible to prove your cure works,, even if it would in humans

A study from a Chinese lab referring to Western diets as toxic and a cause of depression?

	▲	cestith 9 hours ago \| parent \| next [-]
		A Western diet is a transferable thing. Just like in the US we hear about the benefits of the Mediterranean diet or the lower rates of some diseases in Scandinavia or Japan. China has had KFC since 1987. Korean restaurants often have Katsu. Japan has Kobe beef and steakhouses. It’s not some nationalistic plot to say that certain regional diets or their influences on a population are beneficial or harmful in various ways.
	▲	Lalabadie 10 hours ago \| parent \| prev \| next [-]
		I don't think you need to go to China to find that people think the average north American eats terribly for their health.
	▲	zug_zug 9 hours ago \| parent \| prev \| next [-]
		I think given that 75% of americans are overweight and 40% is obese, certainly food would be a very reasonable first hypothesis of any neutral, objective scientist. I would be surprised if food you ate didn't affect energy levels, feelings of wellbeing, etc.
	▲	throawayonthe 8 hours ago \| parent \| prev [-]
		the term western dietary patterns has a more specific meaning: https://en.wikipedia.org/wiki/Western_pattern_diet