> what should be done about open weight bioweapon

The same thing we do about bomb making today, certain ingredients are restricted and/or monitored. Bioengineering is a bigger lift to operationalize.

In other words, don't ban knowledge, make certain applications or ingredients illegal or highly regulated.

And what are those ingredients for biology, which can be constrained as effectively as uranium enrichment? I'd argue there isn't anything which can easily be restricted or monitored.