This comment makes no sense.

Why would anyone make a drug if the current prevalent treatment was as good as a functional cure?

What do lorbrena and keytruda have to do with the rate of failures being constant?

These are examples of ambitious drugs that wouldn’t have been attempted even a few decades earlier. But technology improved and the money was there so they tried anyway, and found success. But for any 3 successes there are still 27 failures because those 27 were equally ambitious.

Keytruda revenue is 30+ billion per year. If your new drug performs 1% better than Keytruda, that revenue becomes yours. If your drug perfroms 1% worse, you become a failure in the statistics.