In this context, something fascinating is https://en.wikipedia.org/wiki/Thermal_grill_illusion

You can artificially induce a burning pain sensation using alternating strips of mildly warm and mildly cold.

Here William Osman of all people builds one of these and uses it on his friends

https://www.youtube.com/watch?v=yw67_k6oDQY

I wonder if this is related to the way bright stripes can be a migraine trigger?