Ketamine treats symptoms and is more like a bandaid from what I see, and comes with its own problems (addiction). Psilocybin and ayahuasca when used properly can help you to process and resolve many types of problems (traumas, past drug/alcohol use, sins). But you have to be willing to work (if you can't bear it alone, this is where the curandero or therapist comes in. If that idea doesn't work for you then probably stick to ketamine)

Everybody's different. I am approaching the problem from multiple angles (pharma, non-pharma); CBT is on the table and I'm open to other non-chemical routes.

Your comment conflates depression with "being sad/hurt". There's biological aspects that no amount of trauma processing (whether talk therapy or spiritual (psilocybin)). Sometimes the machine itself is broken, not the programming.

I've experience significant trauma in my life and, while it shapes my being, is not the basis for my "depression".

Bandaids are valuable tools. I know there are plenty of non-chemical remedies, exercise being a foundational one, that a proper treatment plan includes.

So for everyone, YMMV, but clinical ketamine use has been borderline magical in readily perceptible improvements, with the caveat that it does seem to be temporary. This is a pity, because it's easy to grow mushrooms and DIY in that regard but getting K requires going through expensive gatekeeping.

And to address the addictive concerns of K, for me, the treatments have had their own elements of joy but I see no recreational value for me personally. I've delt with addictive issues in the past and I have no problems facing those particular demons.