There's probably a lot of genetic variation. For some it could be detrimental in 50 years, for others not so much. And for some swath in the middle it could be less than ideal.

> We're already slowly adapting to higher CO2 levels by sitting mostly indoors that have elevated CO2 from 500 to 800 with ranges up to 1500 (taken from my measurements at home).

But won't that 1500 be even higher indoors as CO2 in the atmosphere increases?