If you're not going for pixel art, use the video to video models (the character swap ones that take in a video reference of the animation and a still of the character (the tiktok deepfake models)).

You can e.g. download a run cycle from Mixamo, use Blender to render a video from whatever angle you wish, and feed that into the model along with your sprite on a green background, it's pretty much perfect.

Thanks for the info! I'll give this a shot. Most of my knowledge is from over a year ago, when I would set up OpenPose-style positioning with a controlnet at a high strength to guide an image-to-image workflow in comfyui. But it was pretty tedious and prone to errors.