There's a community of folks maintaining some WINE tweaks to make it work! Thankfully, it's mostly just config options so nothing additional to install/run beyond WINE. I tend to use the V2 suite and on a mac, but I've got Affinity V3 installed on my ubuntu dev machine and had no issues with it when I've needed it.

https://github.com/seapear/AffinityOnLinux

Awesome. Have starred the repo and will have a look through it later tonight when I'm done with work.