I have a PicoGUS and have had a lot of fun futzing around with Claude and porting Cave Story to DOS [1] the last couple of months after SDL announced DOS support.

Originally I was just using it as a Soundblaster, but in the last few weeks added Waveblaster, Adlib, and Gravis Ultrasound support. It's been a lot of fun learning how the GUS works and hearing how distinctively different it is from other sound hardware of that era.

1. https://github.com/ecliptik/doskutsu