I use reader mode on most sites where it is possible. It makes a big difference in most cases. Readable font size and face, good contrast, and comfortable margins. I don't know why so many sites ignore good practices on this stuff.

> I use reader mode on most sites where it is possible. ...

That's my go-to solution on mobile devices almost every single time because on small screens even a good adblocker simply isn't nearly enough to overcome the other issues you mention in your comment here.