For expat most important part of comfort its entertainment and socialization. In cheap areas you will only have locals who depend on country might want or not to socialize with you, but either way cultural gap will be massive and finding friends will be a struggle for most.

There of course cities with a lot of expats and activities, but imagine what - living there is not cheap. Cheaper than US / EU, but you still gonna need that $2000 / month.

Wont even start on topic of lost opportunities from lack of networking since we talk of some extreme downshifting here. But most people need friends and safety net at least.