Drawing/Painting and Cad modeling is very much like games. One hand on the keyboard and the other on the mouse. This mixture can be also done well in other programs. I only bother learning shortcuts for daily tools, not something I use every blue moon.

What I take issue is with tools that make them hard to use with low contrast between widgets or shortcuts that does not work if a text input is focused. Also tools that forget they have a primary usage and wants me to know everything at once (notifications, big action buttons, guided tours and what not).