AKA nanoplastic-induced oxidative stress, but it's actually macrophages (and neutrophils), not T-cells.

The reason this is problem is because cells can never destroy nano-plastic so they keep self destroying forever (chronic inflammation).

I still have my doubts about actual scale of this, especially how we still haven't solved pm2.5 pollution or even asbestos and heavy metals. And then there's PFAS, VOCs, Phthalates and Bisphenols. There's insane amounts of benzene in gas stations and traffic jam, yet no one really gives a fuck (until there's like a ppm in a sunscreen lol).

You are most likely to inhale it due to plastic abundance in environment, just like thousands of other things. It doesn't even have ICD yet. Ingested microplastic unlikely to breakdown while it travels thru your body.

p.s. my partner de-plastified a lot of my life (thru a lot of opposition of me) to the point where a lot of plastic objects feel gross now.

> macrophages

Right, and when it comes to "what happens when the macrophage can't destroy what it engulfed", we can probably learn a lot from parallel work studying tattoos, where the ink-particles are similarly "attacked".

Plus it's a lot easier to create studies or even just observe the cells in question.