I've been daily-driving a Planck with a custom layout for years now. I developed my own layout (QWERTY based but with punctuation and function keys on thumb-driven layers) and it took me a few weeks to get speed parity with my old 104 key, which was rough. But now I can't go back to a standard layout, it's just so much less hand movement that it feels so much better to type on. For gaming it's still a tossup, as most games expect you to have all the same keys in the same places. I've experimented with a "gaming" layer, but lacking a 5th row on the Planck still causes issues with some games.

It still baffles me that the standard layout isn't ortholinear after all these years. There's no reason for staggered rows other than path dependence. But when you have billions of people relying on years of muscle memory on the same layout, it's just not a tradeoff most people are willing to make.