If you have a messy room, you don't throw a grenade in hopes that after explosion things will end up in "better" places than before.

Hence the wisdom of the 'already been there': (Mind)set and setting.

A 'clinical' environment, may not be the ideal setting for some patients.

I don't think psychedelics are going to be any different to any other officially approved psychiatric medicine - we don't know enough to know which subset of patients will respond well vs. poorly for psychedelics any more than already available FDA approved (or equivalent similar organisations for other nations) of psychiatric medicines, which in some cases fuck people over for life after a single dose. Large numbers of people have permanently suffered a massively reduced quality of life as a result of a single Invega injection, yet it's still administered regardless.

All I know, is that we don't know enough to know enough.

My personal empirical experience is that I'm wired backwards and have atypical responses to what is now available due to the clinical phase 3 trial majority response, and have personally suffered from supposed experts applying the 'approved' treatments. Even my current psychologist admits they're in foggy territory which makes her better than previous medical professionals I've dealt with.

Advances in physiological medicine changes before and during my lifetime have been incredible. Advances in psychiatric medicine during my lifetime have been a result of capitalist companies gaming systems to create revenue streams rather than improve the overall well-being of humans. The war on drugs just stifled understanding of what options are out there, and what cause-effect mechanisms exist.

It's nice to see independent studies above and beyond the other end of the extremists (e.g. MAPS) contributing to understanding, even though sample sizes are miniscule compared to what we need.

We're currently gambling/playing the probabilistic statistic odds on psychiatric medications without knowing the 'why/how' they work.

We still don't fully understand the mechanisms of action of Aspirin which was first synthesised well over a century ago, and been in widespread use for many decades.