The psilocybin dosage in this study seems to be miniscule (5mg, 25mg), which is fair given its controversial reputation (undeserved IMO) and researchers’ plausible risk aversion. However, to see meaningful improvements in TRD I’d expect larger doses to be necessary for most people.

~2.5g of psilocybe cubensis is considered a standard dose; according to this [0] study, ~10mg/g is a pretty typical psilocybin concentration in mushrooms, so 25mg of pure psilocybin sounds about right.

[0] https://pmc.ncbi.nlm.nih.gov/articles/PMC11856550/

I'm of the same opinion. Also apparently one recipient ended up with HPPD from this medical study, when they essentially only had 30mg of psilocybin every 6 weeks? I think prior history should be checked there.

> Two serious adverse reactions were reported after psilocybin, 25 mg, including 1 case of hallucinogen persisting perception disorder.

The psychotherapeutic therapy probably did the heavy lifting for any positive effects. At least from what I can tell, for depression, the magic of psychedelics is the reckoning you're faced with to clean up your act and think of more than just yourself.

Still, always glad to see more studies on psilocybin!