Compare it to air planes, which are already at a much more significant scale. Accounting for fuel type and combustion efficiency seems relevant.

I recall around SpaceX 100th landing, that a day of just transatlantic flights was more than everything SpaceX had done to that point

Exactly, they don't matter when compared to general aviation or even just consumer shipping.

And in all cases, if you produce the fuel using renewables then the CO2 output is trivially brought near zero.