Paper title: Disinhibitory signaling enables flexible coding of top-down information in cortical networks

(should be qualified as in-silico visual systems)

Method: replicate fMRI findings of visual abstraction using simple networks to model what's essential

Gist: in tasks 'Inhibitory neurons that suppress other inhibitory neurons seem to pass key information from the “thinking” part of the system to the “sensing” component of the system'

I've heard the same for motor control: it's not that the cortex aims for one action; it aims for a bunch, but most are inhibited. (You see this in chaotic movement when inhibition fails).

So it's not really "think and see" but "what you see when you're doing a task".

(There's some analogy in there wrt (AI) exuberance effacing selectivity in investment decisions...)

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agumonkey 5 hours ago | parent | next [-]

I'm very curious about inhibition failures in brain areas, especially between visual perception and motor control. I'm no neurologist but your brain seems to generate a lot of imaginary interpretation when sensing the visual field, but sometimes there are short circuit like failure that leak those potential imaginary futures with you current real self (leading to strange uncoordinated or overlapping motor control signals)

	▲	nomel 4 hours ago \| parent [-]
		Imbalance of inhibitory and excitatory appears to be the definition/state of a seizure. Apparently, this even goes both directions, as there are also inhibitory seizures, leading to temporary paralysis! [1] [1] https://www.medlink.com/articles/inhibitory-motor-seizures

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MajorTakeaway an hour ago | parent | prev | next [-]

See I did what I saw when doing a task like grabbing for my Guinness to take a swig and ended up hitting my laptop with the bottle when I brought the bottle to my body.

Maybe I have a bit of inhibition going on there.

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milleramp 5 hours ago | parent | prev [-]

"inhibition fails" reminded me of this passage from Fear and Loathing.

"Ah, devil ether. It makes you behave like the village drunkard in some early Irish novel... total loss of all basic motor skills. Blurred vision, no balance, numb tongue. The mind recoils in horror, unable to communicate with the spinal column."

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willy_k 4 hours ago | parent [-]

It’s worth noting that in neuro speak, inhibition does not necessarily correlate with what would appear to be a “dis/inhibited” person; it’s referring to a specific process where signals are blocked from propagating, and because the brain is made of a complex web of inter-modulatory loops, this can show up in unintuitive ways

e.g. signals from the default mode network getting in the way of task-oriented behavior, which can result in people appearing “inhibited” where in actuality they’re failing to inhibit irrelevant internal signals and (errant bottom-up) attention to them (this is the case in ADHD).

	▲	taneq 3 hours ago \| parent [-]
		Think of it like a relay with a normally closed contact.