isn't this just a by-product of seed hybridization which has enabled pretty much all of modern agriculture? A lot of testing goes into finding the two strains that combine together to create high-yield seeds, but the next generations of those seeds won't produce well.

Almost true. For many plants, a hybrid is naturally unstable, and can often be stabilized with one extra cross. (But isn't, as it serves as intellectual property protection for the seed company.) But some plants, soy beans being a biggest cash-crop example, can not be bred to be unstable. (See my comment above about Monsanto Roundup-Ready beans.)