I'm not sure about macOS, but it is seamless on Linux for my use cases. One thing to note is that Podman Compose defaults to docker-compose as the provider, and I haven't used the podman-compose provider (confusingly named slightly different to Podman Compose, which is the top level abstraction on top of docker-compose or podman-compose). You can still run containers through the Docker engine with Podman, if you need to.