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bensyverson 3 hours ago

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work.

That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can imagine?

arjie 3 hours ago | parent | next [-]

Yes, mechanically constructing life would be absolutely stupendous for science. The real tragedy of modern sci-fi is that everyone read the books and decided it was reality.

“Penicillin?! A poison from fungus that kills living cells?! Haven’t you played the sci fi game The Last of Us?”

Stories are stories, man. Story-logic is biased towards interesting tales. And “discovery from the natural world turned to human aims with great results” is uninteresting because we do amazing things these days.

senkora an hour ago | parent | next [-]

> Stories are stories, man. Story-logic is biased towards interesting tales.

Also known as the fallacy of “generalizing from fictional evidence”.

https://www.lesswrong.com/posts/rHBdcHGLJ7KvLJQPk/the-logica...

arjie 6 minutes ago | parent [-]

Hilarious. Everything that I can think of has been already Yuddocumented. I am but a minor replicant LLM of the man. https://wiki.roshangeorge.dev/w/Story-Logic_Bias

I don't spend any time on LW but perhaps that is because I'll have to face that all my ideas have already been explored more eloquently by him and the communities he's part of.

dbingham 2 hours ago | parent | prev [-]

I think the issue is that those stories are rooted very much in the failures of human systems that we see every day. They are us imagining what could go wrong based on what has gone wrong and is going wrong.

It would be a lot easier to set those warnings aside if we didn't have so many examples of the very things they warn about happening in real life.

We currently have a system where private individuals can fund private science and then deploy the results globally to their own profit with very few mechanisms for enforcing restraint and caution. And we've seen this backfire with horrific consequences over and over again.

Lead in the gasoline. Microplastics in the water. Pesticides widely applied to the biosphere. In my area PCBs are a massive risk due to past soil contamination. In other areas fracking biproducts make the water undrinkable.

Hell the AI rush in the face of climate change. We literally have heatwaves killing massive numbers of people while a tiny handful of investors and the companies they control are drastically increasing our carbon emissions in the race for AI.

It's easy to imagine all the ways in which synthetic life could go horribly wrong, even with out those sci-fi stories, especially since all but the youngest of us have been through a brutal pandemic in living memory.

It's very, very hard to imagine our current system showing proper restraint with this technology.

Zambyte an hour ago | parent [-]

It's important to emphasize that cars are the leading source of carbon emissions. Anyone fighting against AI on the basis of climate change should be fighting for safe and reliable alternatives to driving everywhere.

dbingham 37 minutes ago | parent | next [-]

This is "whatabboutism" which is a logical fallacy.

Someone doesn't have to talk about the climate impacts of cars every time they talk about the climate impacts of AI. Both have climate impacts, independently of each other, and we should be dealing with the climate impacts of both simultaneously.

Regardless, don't assume the person you are talking to isn't consistent. Peruse my personal blog and you will see that I, in fact, ran a whole city council campaign on a platform of "to fight climate change we should not be driving".

CamperBob2 33 minutes ago | parent [-]

Someone doesn't have to talk about the climate impacts of cars every time they talk about the climate impacts of AI.

Actually they do, because the best way to get cars off the road is to replace many if not most of their occupants with AI.

Private ownership of cars is not the problem. The assumption that people have to drive all over the place to get stuff done is the problem. Let's work on that.

feoren 23 minutes ago | parent [-]

> the best way to get cars off the road is to replace many if not most of their occupants with AI.

I'm so confused by this. Instead of one person driving a car to the store and parking, now the car is driving itself to the store with one person in it, dropping them off, and then either parking, or driving itself around more, back to the house or to a distant parking facility. In crowded cities, the car is just going to drive around the block empty for an hour instead of paying $12 for parking. Single-occupancy vehicles are a big problem now; I don't understand how introducing a bunch of zero-occupancy vehicles are an improvement on that? It seems very obvious to me self-driving cars are going to significantly increase the total number of miles driven every day in the world.

NetMageSCW 21 minutes ago | parent | prev | next [-]

That’s just wrong. Transportation is 24% of carbon emissions with 18% road transportation and about 10% of that from cars. Electricity and heat production is the largest source of carbon emissions.

flurpitude an hour ago | parent | prev | next [-]

Should also be fighting for that.

CamperBob2 an hour ago | parent | prev [-]

And the most promising of those alternatives is, ironically enough, AI itself. Fighting data centers is literally like fighting nuclear power. If you just want more carbon emissions, then by all means, proceed.

Of course most people who commute to work don't need to be doing that now, but that's the other big elephant in the room with AI. We don't use the intelligence we already have, so what makes us think the emergence of ASI/AGI will change anything?

mattlondon 2 hours ago | parent | prev | next [-]

> That is the holy grail?

At one end we're creating artificial life, the other we are creating artificial intelligence.

We're coming at everything we as the human race have known for millennia from both ends, simultaneously. We're recreating that, from scratch.

That is absolutely fucking wild.

Ironically this "holy" grail will end up being the thing that finally puts religious creation myths in their place (i.e. as bullshit) since we will be able to answer with 100% certainty that we are not alone or unique in the universe since we recreated life in the fucking petri dish so why not across the billions and trillions of other planets out there?

What a time to be alive.

graemep 38 minutes ago | parent | next [-]

> Ironically this "holy" grail will end up being the thing that finally puts religious creation myths in their place (i.e. as bullshit) since we will be able to answer with 100% certainty that we are not alone or unique in the universe since we recreated life in the fucking petri dish so why not across the billions and trillions of other planets out there?

How does it affect religious ideas per se? its something many religious people long to find https://www.theatlantic.com/culture/2026/06/disclosure-day-a...

yreg 2 hours ago | parent | prev | next [-]

> we will be able to answer with 100% certainty that we are not alone or unique in the universe since we recreated life in the fucking petri dish

I don't think we are alone, but this is not logically sound. The conditions in the petri dish might be easily so special that their natural prevalence is < 1 per universe.

gmueckl an hour ago | parent [-]

The first time this happens in a petri dish will likely have to be under extremely controlled circumstances. But the process will be modified and toyed with once it exists and I think that this will eventually lead to whole spectrum of (quasi?)biological systems that together cover a broad range of environmental conditions.

el_io 2 hours ago | parent | prev | next [-]

You if believe creating life will end religion then you're wrong.

We thought evolutionary theory would do the same, now we got people who believe god directed evolution. Some believe everything evolved from a common ancestor except Humans.

So the believers will adapt to believe that Genesis was talking about exactly this.

graemep an hour ago | parent | next [-]

Who thought evolutionary theory would end religion? Sounds like wishful thinking from people who were hoping for an end to religion.

Mainstream Christianity was not not biblical literalist anyway. Read what Augustine or Origen had to say about interpreting Genesis.

ZenoArrow an hour ago | parent | prev [-]

Science can't disprove religion. Consider the "big bang", is that any less of a miracle than "God did it"? Science is like "just give us one miracle and we'll explain the rest".

groceries8192 an hour ago | parent | next [-]

The big bang theory isn't even incompatible with the idea that 'God did it'; the idea was first proposed by a Catholic priest, as a matter of fact! I think the anti-science stance of evangelicals has eclipsed in the modern consciousness the fact that modern science owes much to the Catholic church.

> This startling idea first appeared in scientific form in 1931, in a paper by Georges Lemaître, a Belgian cosmologist and Catholic priest.

excerpt from https://www.amnh.org/learn-teach/curriculum-collections/cosm...

nathan_compton an hour ago | parent | prev [-]

I think this is really the wrong framing. Science can't disprove religion. The question is whether it makes any sense to believe in the religion in the first place, given what observation and science say about the universe. Science can't prove that God didn't create the universe a nano-second ago in exactly the state to produce this temporal evolution, but no one believes that because its not explanatory and also fails a bunch of other, not-necessarily scientific, but rationally motivated epistemological tests.

The way I see this is that science cannot disprove any particular religion, but it can probably offer more compelling explanations for the state of the world than religion can offer. People haven't flocked away from religion because explanations for the state of the world aren't really what people want from religion. They want a sop for their anxieties. they want community, etc. I think believing in nonsense is a real shitty way to get these things, but I'm not most people.

kilobaud 2 hours ago | parent | prev | next [-]

(Disclaimer: on religion I try to be respectful, as an agnostic atheist) I do think our ability to “build tools that create life” is incredible, but to me has a limited argumentative impact on what I guess you could call the “prime mover” question: _But how did everything start?_ Does that seem reasonable or am I downplaying the implications you mentioned?

system33- 2 hours ago | parent | prev | next [-]

Nah. The natural pivot is from “we have never observed abiogenesis” to “see? Life required a creator.”

You can’t win

groceries8192 an hour ago | parent | next [-]

Thomas Aquinas made the argument that all life comes from other life in the 13th Century. I wouldn't classify it as a modern pivot so much as one of the central philosophical arguments for the existence of a Creator.

Windchaser an hour ago | parent | prev [-]

Aye, but this will let us gradually work towards more and more basic cell forms, so that we can eventually figure out abiogenesis.

lo_zamoyski 3 minutes ago | parent | prev | next [-]

Not really. AI isn't intelligent by any stretch. To make that claims requires ignorance of what constitutes "intelligence", especially the most essential element of intelligence, viz., intensionality. LLMs or expert system or whatever absolutely lack intensionality by definition because computation is by definition a purely syntactic process.

> Ironically this "holy" grail will end up being the thing that finally puts religious creation myths in their place

I think you're way out of your depth here and making things up. The first tell is that you speak of "religious" as a blanket term as if all religious traditions make the same claims, which they absolutely do not. You can discredit, say, Mormonism much more easily than, say, Islam (though, ironically, there is a strange structural similarity between the two).

> we will be able to answer with 100% certainty that we are not alone or unique in the universe since we recreated life [..] so why not across the billions and trillions of other planets out there?

Who exactly claims that human beings or, generally, life on earth are the only life in the universe? None of the major religions do. I'm also going to assume that Christianity (or some caricature of it) is for you the paradigmatic reference point of what constitutes "religion", in which case there is nothing in Christian theology that excludes the possibility of life - even embodied intelligent life - elsewhere in the universe. (The latter is actually interesting from an ontological perspective. If the definition of "human" is "rational animal", then by definition, all rational animals are human. So, from an ontological perspective, even if an intelligent, phylogenetically distinct species were to be found on another planet, ontologically, they would also be human.)

namero999 an hour ago | parent | prev | next [-]

I might in some sense agree with you but check your wording: creationism... we recreated life... see where I'm going?

AndrewKemendo 2 hours ago | parent | prev | next [-]

That’s because we’re almost to the Technological Singularity

Kurzweil puts it between 2029-2032 and that seems right to me

https://en.wikipedia.org/wiki/Technological_singularity

tsunamifury 2 hours ago | parent | prev | next [-]

Wait you think creating life disapproves creationism?

I’m no 7 day creationist but haha my guy…

2 hours ago | parent | prev [-]
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TSiege 3 hours ago | parent | prev | next [-]

I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it would be to create completely from scratch. We already do this with the process known as precision fermentation. We've gotten very good at editing genomes via CRISPR and related techniques and are only getting better

https://en.wikipedia.org/wiki/Precision_fermentation

senkora 3 hours ago | parent | next [-]

It seems like this cell barely evolves, because the system they built for duplicating the DNA makes very few errors.

Natural life tends to evolve, which may have consequences for production.

For example, quorn production has to be restarted from a seed population after ~1000 hours because it tends to evolve colonial variants that break the product standards: https://www.davidmoore.org.uk/21st_century_guidebook_to_fung...

TSiege 3 hours ago | parent [-]

Very interesting! Thanks for sharing

PaulHoule 3 hours ago | parent | prev | next [-]

It's desirable to have some kind of simple base to start from that is an easy-to-configure platform to deploy any kind of metabolic machinery.

Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo!

This is more like it

https://www.jcvi.org/research/first-minimal-synthetic-bacter...

but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"

colordrops 3 hours ago | parent | prev [-]

It seems that eventually you could build much more flexible and powerful if you build from scratch. Hacking existing cells is a shortcut but longer term we may get grey goo.

3 hours ago | parent | prev | next [-]
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JumpCrisscross 3 hours ago | parent | prev | next [-]

> That is the holy grail?

If you can disassemble and reassemble a thing, you can say you understand it. Not perfectly. But understand it. I’d imagine properly understanding rudimentary cellular biology will come with perks.

(Also, does the Holy Grail imply both a boon and a cost? Or is that just Indian Jones.)

tialaramex 2 hours ago | parent [-]

To your aside: No, in this abstract sense Holy Grails are just a boon, a desirable piece of knowledge, achievement, that sort of thing.

yread 3 hours ago | parent | prev | next [-]

I think one useful application of this would be life built on stuff that doesn't interact with our cells - artifical bases, nucleotides and all. Then we could have non-biological self-replicating robots

adrian_b 3 hours ago | parent | prev | next [-]

While this is an impressive step forward, there remains an extremely long way, probably of several decades, until being able to design and synthesize a cell comparable in complexity with a bacterium.

The thing that they made is more alive than a crystal, which when placed in a suitable solution will grow and reproduce its own structure, but much less alive than even the simplest known living cells.

Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels.

The techniques developed to make this pseudo-cell might evolve eventually into techniques able to make a true cell and it is likely that valuable information can be extracted from experiments with it, but it is very unlikely that any of the ancestors of the living beings has ever had even a remote resemblance with this (because it is far too dependent on continuously receiving complex cellular components and nutrients from outside; simplified parasitic living beings could appear only when there already existed sufficiently complex living hosts for the parasites).

Some components of this thing are growing by reproducing themselves, but like I have said, so does any crystal, thus it is difficult to choose a criterion that will distinguish with certainty what is living from what is non-living.

The growth is followed by a kind of division into 2 vesicles, but that happens by a mechanism very different from any living cell. Many inorganic things will split when growing over a certain size, so again it is hard to decide whether this can be called living.

danans 3 hours ago | parent [-]

> Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels

A brain-dead human is alive, but just facing systemic collapse, aka death. That's not to imply that what the scientists here have created is alive, but the comparison isn't so apt.

adrian_b an hour ago | parent [-]

As a multi-cellular organism, a brain-dead human is not alive, even if most of its cells may remain alive as long as they are fed from outside.

OK, what I have said above is not generally true, as some brain-dead humans may be more alive than others, e.g. some integrative functions, like some feedback loops that function through the endocrine system or through the autonomous nervous system, may still be working, connecting some organs with each other.

My comparison was with a very dead brain-dead human, who was reduced to the equivalent of a tissue culture.

These artificial cells also have some components that continue to work like in a living cell, doing some nucleic acid replication and some protein and lipid synthesis from precursors provided from outside, but they lack the capability to perform many of the chemical reactions that would be needed to close the complex network of feedback loops that enable a true living cell to live autonomously.

dukeofdoom 2 hours ago | parent | prev | next [-]

Yeah, imagine if one day it will become trivial to blow up the world. Enough people hate humanity that they would do it, by tomorrow if they could. Seems like out exponential growth in technology will eventually lead up to that. If not actual nuclear explosion, then biological weapons. Would we need to enslave humans not to do it. How would that work.

iwontberude 2 hours ago | parent [-]

I agree with your conclusion. We start by enslaving certain classes of humans like Peter Thiel or Elon Musk. Anyone with more than $1B gets the collar. Populism is a helluva drug.

fouc 3 hours ago | parent | prev | next [-]

Have you not seen Jurassic Park?

Legend2440 3 hours ago | parent | prev [-]

Man, I am so tired of the cynicism around here.

Anytime you do something interesting or useful someone accuses you of trying to build the apocalypse.