The only way they could even consider making it work would involve blessing certain kernel builds, and their integrity would need to be verified. If I am able to swap out the kernel, anti-cheat cannot be effective.

Ubisoft added Easy Anti-Cheat support for Linux and Valve's Proton compatibility layer. I play Division 2 and it runs just fine. More of them are being added by the AAA studios. Missing is Vanguard / Riot Anti-Cheat, no idea when that will get added. Thus far games have not tried to dork with my kernel.