It won't. Once you actually visit Bruxelles or talk with ex-policymakers you realize they don't actually care to give up sovereign control to the EU.

It's still viewed as a prestige post, and European industries and states will continue to work with partners outside of Europe if it means surviving.

Additonally, capital consolidation within the EU also means subnational capital flight which means layoffs. For example, look at how East Germany shifted hard to AfD after Germany Inc left for Poland. Therefore, when push comes to shove, it becomes politically untenable.