Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

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faangguyindia 10 hours ago | parent | next [-]

I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person.

So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?

Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations.

Don't quote me on this; I am paraphrasing things I remember from.

	▲	Terr_ 9 hours ago \| parent [-]
		https://pmc.ncbi.nlm.nih.gov/articles/PMC3405064/ > Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure. > So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members? P.S.: One theory I've seen is that the extra sedentary-spend is in the immune-system, which may have both beneficial and harmful effects, depending on whether it's doing useful work versus causing problems.

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spbaar 11 hours ago | parent | prev | next [-]

Thirst affects me in a different way too. My throat doesn't feel dry and uncomfortable because before it reaches that point I almost get naseous.

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npunt 13 hours ago | parent | prev [-]

oh say more?

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cjbgkagh 13 hours ago | parent [-]

This is why I took it, auto immune related ME/CFS. Works great. I still get PEM but outside of that I get to live a normal life.

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emmelaich 10 hours ago | parent [-]

Interesting! Is it possible that you're just eating less of whatever triggers the autoimmune symptoms?

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cjbgkagh 10 hours ago | parent [-]

No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.

	▲	s5300 7 hours ago \| parent [-]
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