Tirzepatide at 1mg/week reduced my muscle soreness. I felt less depressed but this might just have been situational because I've been plagued by bad soreness after working out for years.

Unfortunately after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen, and was worried it might be pancreatitis developing. I'm not sure why it would happen at such a low dose but the symptoms reduced pretty quickly as it wore off.

I may go back on later with a dose spread over a longer period with the hypothesis that the drug has a longer half life in my body and what I experienced was a gradual build up. Considering I lost 15 pounds over 3 months as well, I believe this to be very plausible.

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tapoxi 13 hours ago | parent | next [-]

I got pancreatitis from Zepbound, but it was indirect.

Turns out rapid weight loss can cause gallstones, especially if you're genetically predisposed to them. I had one that ended up stuck in the bile duct, causing acute pancreatitis. I had to get my gallbladder removed shortly after and hundreds of stones were found.

I would consider getting an ultrasound since the stones don't just go away when you stop taking the drug.

(Gallbladder removal aside I had no lasting issues and kept the weight off.)

	▲	perilunar 7 hours ago \| parent \| next [-]
		Wouldn't that be cholecystitis (and a cholecystectomy), not pancreatitis?
	▲	zhivota 12 hours ago \| parent \| prev [-]
		Thanks for sharing, it makes sense. Even before taking Tirzepatide I have had issues my whole life with greasy / fatty stool, and now that I've had reason to research the gall bladder, it does make me wonder if perhaps I also have stones.

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rossdavidh 9 hours ago | parent | prev [-]

Might be worth trying live yogurt in the meantime, per the article?

	▲	zhivota 9 hours ago \| parent [-]
		Yep one thing I did as part of going off tirzepatide was go immediately on a high fiber and fermented foods diet. It has helped a lot actually. It's quite hard to maintain over time is all, I have a lot of social occasions where healthy choices are not really available, and from experience I know that over time I'll slowly drift back towards an unhealthy eating pattern. The modern world is just geared that way, unfortunately.