It's pretty great in my toy emulator project (https://github.com/floooh/chipz) as 'system bus' where each bit is a 'wire' which is then mapped to chip input/output pins.

The bus-width is a generic parameter and can be below or above 64 bits (depending on the emulated system). With arbitrary-width integers the high level code remains the same no matter what the bus-width is, and from looking at the compiler output, as long as bit operations don't straddle the underlying 64-bit integer boundary, those bit operations are just as efficient as working on a simple 64-bit int.

Also AFAIK LLVM supports arbitrary-width integers since pretty much forever, Zig just 'exposed' them in the language (as later did Clang via _ExtInt(N), which is now deprecated in favour of C23's _BitInt(N)).

The other nice usage (also in emulators) is for chip registers and counters, those often have odd widths (like 5 bits), and writing those as u5 instead of u8 in the code is just nicer since it matches the chip documentation, and when reading the code it's immediately clear that this u5 is a 5-bit counter or register.