I am in the US currently, would be managing initially from the US. I understand there will be US tax complications, but I can/would deal with those.

I saw this a lot when I ran BD for the program (I'm also an American) and its good you know there will be US tax complications but I would say that unless you expect to 1) have many EU customers and 2) working remotely globally and redomicile elsewhere so you are not considered US tax resident that it probably doesn't make more sense than using something like Stripe Atlas to just set up an LLC or C-Corp

Unless you have some specific reason for being in the EU, I suggest you also look into Singapore.

The worst thing you could do as an us citizen (I assume ) and resident is to incorporate outside of the US.

This is a terrible idea. please hire a professional with direct experience on these matters and not blog posts from influencers